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The qualifying comorbidities deserve attention because many people have them without realizing it

AGEs cause direct oxidative damage to skin cells and alter protein structures, potentially creating new targets for an already overactive immune system to attack

doi: 10.1007/S10067-021-06001-1 111 McMahonDEGallmanAEHruzaGJRosenbachMLipoffJDesaiSRet al