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The model results support the discussion in [13] of why this is so

That balance is the more interesting readout of the two, because a compound that raised both synthesis and degradation would look very different in a remodeling assay from one that shifted the ratio

Studies using rat pinealocytes demonstrated that Epithalon upregulates both arylalkylamine N-acetyltransferase (AANAT) and phosphorylated CREB (pCREB), the rate-limiting enzymes in melatonin synthesis