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In addition, ACA decreased the expression of T-helper type 2 cytokines and inhibited T-helper type-1 cytokine release, overexpressed during asthma induction
This double-blind, placebo-controlled study showed that topical application of palmitoyl pentapeptide-4 for 12 weeks significantly reduced wrinkle surface area (up to a 36% reduction ), wrinkle depth and skin roughness, with results comparable to those of retinol 0.07% but without any irritation
Acta MedicaMediterranea 32:16431649 Bush AI, Tanzi RE (2008) Therapeutics for Alzheimer's disease based on the metal hypothesis
In turn, activation of macrophages leads to the secretion of interferon- (IFN-), which can downregulate the expression of SLC7A11 and inhibit GSH synthesis, thereby promoting ferroptosis and clearing infected and tumor cells (15)
10.1172/JCI115499 J Clin Invest
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