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One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits
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Stem cell therapy may justify its higher cost in chronic degenerative conditions like moderate knee osteoarthritis or failed conservative management of tendinopathy, where moderate-quality human evidence supports symptom reduction despite lack of structural regeneration
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