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Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life

These microthrombi obstruct capillaries, causing local blood flow interruption and forming a no-flow phenomenon, resulting in inadequate blood and nutrient supply to renal tissue and further exacerbating cellular hypoxia injury [44, 45]

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Notably, recent research has identified novel nonhistone lactate transferases, expanding our understanding of lactylation mechanisms