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Researchers investigate Big picture view: In the study, researchers at the University of Virginia specifically investigated small-molecule GLP-1 receptor agonists, such as the Food and Drug Administration (FDA)-approved orforglipron, which can be taken orally and are cheaper to produce than their injectable counterparts

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As the oxidative burden on the nervous system decreases, the autonomic nervous system can begin to shift back toward parasympathetic dominance (the "rest-and-digest" state)

The primary outcome was the occurrence of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke