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Hypoestrogenism, particularly of estriol, generates a group of symptoms known as the climacteric, which are characterized by vasomotor alterations, urogenital atrophy, and a series of metabolic changes, among other symptoms, which directly affect womens quality of life (Santoro and Randolph, 2011

Hooshmand B et al., Neurology 2010 B12 status and brain volume in elderly

ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice

[PMID: 8852702] PubMed record related to this compound for laboratory literature review

Evidence for this use is still developing and should be discussed with the treating oncology team as part of the overall care plan