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5.4 Considerations for intranasal delivery IN delivery provides a non-invasive and accessible dosing route for medication administration, but it also has several concerns that necessitate careful consideration

Each problem requires a different approach

Pregnancy dramatically increases acetaminophen toxicity risk : 80% increase in the toxic pathway, 43% HIGHER toxic NAPQI in first trimester, 33% LESS safe sulfation capacity, and glutathione depleted by 36-87% throughout pregnancy

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Very rarely, more serious reactions can occur, such as a severe allergic reaction