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Specifically, GLP-1RAs exert protective effects on exercise-induced cardiomyopathy via increasing autophagy, reducing inflammation-related proteins and ROS generation via restoring the expression of catalase and manganese superoxide dismutase (MnSOD) [81]

Timing and lifestyle factors Heart rate naturally fluctuates throughout the day, and certain factors can amplify the effects of retatrutide on cardiac rate: Caffeine is an adenosine receptor antagonist that independently increases heart rate

The American Journal of Clinical Nutrition, 96(6), 1281 to 1298