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However, more studies are needed to determine the safety of H4R blockers as induction agents or in the setting of coexisting infections based on the importance of the histamineH4Rneutrophil innate immune axis demonstrated in our study
Building on this model, we integrate network pharmacology and graph theory to rank the therapeutic impact of DM2 DMTs, including metformin, on AD-related pathways within a DM2-AD comorbidity network (see Fig
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