Together, these studies indicate that activation of NTSVTA projections is sufficient to reduce cocaine seeking during abstinence and that drug seeking is more sensitive to central GLP-1 modulation than non-drug motivated behaviors in cocaine-experienced rats
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However, the substitution of residues Glu22, Glu27 and Ala30 of GLP-1 with Gly16, Leu21 and Glu24 of exendin-4 enabled Gly2 tolerance 32
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Compared to Veh, RETA treatment significantly enriched the expression of genes associated with several Hallmark pathways such as TNFA signaling via NFB, interferon gamma and alpha responses, and inflammatory response which are associated with enhanced anti-tumor immunity (Fig