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In the presence of metal ions, they chelate and produce OH radicals by decreasing H 2 O 2 (Fig
In addition, Liver cancer is more dependent on FSP1 overexpression mediated by Keap1/Nrf2 to inhibit ferroptosis, and using FSP1 inhibitor iFSP1, FSP1 effectively induces ferroptotic cell death in liver cancer and profoundly increased immune infiltrates to unleash anti-cancer immune response (Cheu et al., 2023)
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In clinical trials of FDA-approved semaglutide and tirzepatide, participants using medication plus lifestyle changes lost more weight than placebo groups
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