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During development, blood endothelial cells (BECs) are differentiated into arterial and venous EC subsets, in a process controlled by Notch signaling pathway ( Prospero homeobox protein 1 ( PROX1 ), SRY-Box Transcription Factor 18 (SOX18) and NR2F2 ( Endoglin , the Vascular Endothelial Growth Factor Receptor (VEGFR)-1 and Angiopoietin 1 ( ANGPT1 ), as well as proteins involved in signaling pathways that regulate blood flow and vascular permeability, such as NADPH Oxidases (NOX) and Rho GTPases ( Table 1 )

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