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If you lose muscle, your metabolism slows down (which is one reason rebound weight gain is so common for people who have lost a lot of weight)

In a combined multiple ascending dose and Phase IIa study in people with type 2 diabetes over 41 days, daily doses of cotadutide up to 200 g improved fasting and postprandial glucose levels and reduced body weight compared with placebo [79]

doi: 10.2527/jas.2008-1428 69 DingJ.ZhangS.RazanajatovoR

For larger volumes, repeated dosing or clients with limited deltoid mass, the ventrogluteal site is the safer alternative: it carries the greatest muscle depth and sits away from major nerves and vessels

This is crucial to understand as eating too few calories can trigger 'metabolic adaptation' - where your body adapts to lack of fuel by burning fewer calories