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Agus DB, Gambhir SS, Pardridge WM, et al
MGSH is the main line of defense for the maintenance of the mitochondrial redox environment to avoid and repair oxidative modifications that lead to mitochondrial dysfunction and cell death (Mar et al., 2009)
doi: 10.1089/thy.2020.0299 90 FaamBGhadiriAAGhaffariMATotonchiMKhorsandiL
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Additionally, RSL3, a direct inhibitor of GPX4 [292, 293], reduces the enzymes activity and promotes lipid peroxidation, thereby enhancing ferroptotic death in TNBC cells
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