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In contrast to the contrasting views on the impact of GIP on the weight, earlier studies unequivocally demonstrated the weight-reducing effects of GLP-1 and GLP-1RAs in both animals and humans

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Appl Physiol Nutr Metab 40:280291 Zanelli SA, Solenski NJ, Rosenthal RE, Fiskum G (2005) Mechanisms of ischemic neuroprotection by acetyl-l-carnitine

Only tirzepatide (Table 1) has demonstrated a significant effect on resolution of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis improvement (that is, resolution of MASH without worsening of fibrosis and a reduction of at least one fibrosis stage without worsening of MASH)