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Maximum recommended daily caffeine intake for adults: 400 mg (EFSA)
The dual mechanism provides complementary glucose-lowering effects through amylin-mediated glucagon suppression and GLP-1-mediated insulin secretion
Relative to the corresponding reference agonist used in the same assay, retatrutide showed lower potency at GLP-1R and GCGR and higher potency at GIPR
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