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Conversely, mice defective for both the receptors for glucagon and GLP-1, or GLP-1 and GIP, show a highly plastic entero-pancreatic system that adapts and gives these animals no overt phenotype in terms of glucose homeostasis ( Nonetheless, the pharmacological activation of the GLP-1R is clinically beneficial (179), offering an improved glycaemic control with lower cardiovascular morbidity and without the risk of hypoglycaemia associated with some current anti diabetic drugs (173)

Common adverse reactions include local injection-site discomfort, redness, or swelling

Oral semaglutide works by mimicking the natural GLP-1 hormone to promote fullness and reduce calorie intake when combined with healthy lifestyle changes

Rom Biotechnol Lett 18:85598572 Boondaeng A, Kasemsumran S, Ngowsuwan K, Vaithanomsat P, Apiwatanapiwat W, Trakunjae C, Janchai P, Jungtheerapanich S, Niyomvong N (2021) Fermentation condition and quality evaluation of pineapple fruit wine

It may be suitable for those primarily managing diabetes but also looking for mild weight loss benefits