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Errores innatos del metabolismo La acidemia metilmalnica (MMA) La existencia de un transporte facilitado materno fetal de casi todas las vitaminas ha estimulado la tentativa teraputica intratero con vitaminas (cianocobalamina, biotina, rivoflavina y piridoxina) a fetos con presunto trastorno metablico dependiente de vitaminas (mutaciones de la aciduria metilmalnica, homocistinuria sensible a B6 y deficiencia mltiple de carboxilaxas)