The enzyme cystathionine--synthase (CBS) that catalyzes the first step in the transsulfuration pathway is highly expressed in liver cells but not highly expressed in peripheral cells, so it is not surprising that the liver is the major producer of GSH, much of which is exported to the plasma and enzymatically broken down to cysteinylglycine and cyst(e)ine that is subsequently taken up by other cells for GSH synthesis
[Published corrections appear in Lancet
Medication and medical conditions : Studies have shown that certain drugs such as several diabetes medications (including insulin and sulfonylurea), antihypertensive drugs, beta-blockers, calcium channel blockers, and psychotropic medications can have an effect on weight gain
Ectopic suicide inhibition of thioredoxin glutathione reductase
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