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10.1016/j.fertnstert.2008.09.064 101 PazzagliaE.PraetJ.VandrommeJ.RozenbergS
Approximately 40% of patients carry mutations in Norrin/-catenin pathway genes
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The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)
These findings highlight the importance of TREM2 in promoting microglia polarization to the M2 anti-inflammatory phenotype and alleviating cognitive dysfunction ( 2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment
