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( GLP-1 RAs recently appearing on the market, in particular liraglutide, semaglutide and tirzepatide (a GIP/GLP-1 RA dual agonist) seek to overcome the problem of the short plasma half-life of native GLP-1 through (i) changing the amino acid sequence of the peptide so that it is no longer broken down by DPP-4, and/or (ii) attaching a long acyl chain to the peptide, thus allowing it to bind to albumin, and avoid rapid elimination via the kidney

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The drugs currently cost about $1,000 per months supply, or about half that amount if patients obtain them directly from the companies through newly launched direct-to-consumer programs

Just last week, Lilly revealed new phase 2 findings for oral orforglipron that show it can induce clinically meaningful weight reductions in overweight or obese adults

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