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Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)

Reality check: While the mechanism for lightening is plausible in laboratory settings, real-world clinical results vary

These agents work through local osmotic effects in the colon and are not systemically absorbed to any significant degree

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Chronic inflammation links cardiovascular, metabolic and renal diseases