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You start at 0.25 mg weekly for 4 weeks, increase to 0.5 mg for 4 weeks, then 1.0 mg for 4 weeks, followed by 1.7 mg for 4 weeks, reaching the target dose of 2.4 mg weekly

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This may lead to subtle changes such as: slightly increased appetite return of mild food cravings changes in blood sugar control for some individuals However, these effects typically occur gradually rather than suddenly

Yu Y, Jin L, Zhuang Y, Hu Y, Cang J, Guo K

It was a population of older postmenopausal women, a meaningfully different biological context, in whom initiating hormone therapy may carry different risks than initiating it earlier [11]