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Furthermore, according to reports, 85% of patients experienced tendinopathy within 1 month after fluoroquinolone treatment, and 41%50% of patients presented with symptoms after discontinuation of fluoroquinolone (Lewis and Cook, 2014)

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IFN- binding to its receptor activates the downstream Janus Kinase (JAK)-STAT pathway, resulting in the phosphorylation of STAT1 (p-STAT1) ( Moreover, glycyrrhizin can inhibit the expression of fibrosis-related factors such as Connective Tissue Growth Factor (CTGF), Matrix Metalloproteinase (MMP2), and MMP9, reducing basement membrane disruption and inflammatory cell infiltration ( 4 Clinical applications and efficacy evaluation 4.1 Viral hepatitis High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that promotes inflammatory responses in viral hepatitis