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For example, in experimental arthritis, it has been demonstrated that the systemic administration of ACs protected mice from autoimmune arthritis by inducing regulatory B cells, thereby restraining inflammatory responses [41]

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343 Supplementation with NAD + precursors, NR and NMN, elevated NAD + levels that can maintain the mitochondrial and metabolic functions by activating SIRT1 in mice, leading to an extensive lifespan of mice

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