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K.DuX.WangY.LiD.et al (2022)

Particles (209,000) from the best looking class were subjected to 3D auto-refinement in RELION 2.03

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion

Many patients find their ideal window after 23 weeks of experimentation

How Weight Loss Affects Nerves: Peripheral nerves are surrounded by fat Rapid fat loss changes nerve microenvironment Mechanical stress as tissues shrink around nerves Altered blood flow to nerves as vascular beds change Supporting Evidence: Higher doses (more weight loss) = more dysesthesia Doesn't occur early (takes time for substantial weight loss) Not seen with slower weight loss medications Theory 3: Metabolic Changes Retatrutide produces dramatic metabolic shifts: improved insulin sensitivity, altered lipid metabolism, changed glucose homeostasis