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Beyond the absolute contraindications, several situations call for heightened caution in the class framing and are firmly a clinicians domain: a history of pancreatitis or symptomatic gallstones, significant gastrointestinal motility disorders (such as gastroparesis, which slowed gastric emptying can worsen), diabetic retinopathy that is not stabilized, severe renal impairment where dehydration from GI side effects raises risk, and any concurrent use of insulin or a sulfonylurea, where the additive glucose-lowering can produce hypoglycemia

Aflibercept for the treatment of macular edema secondary to idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome

This research firmly establishes oxidative stress as a shared mechanistic basis for these conditions and underscores the critical need for targeted antioxidant therapies to protect cellular infrastructure

Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy

Fourteen of sixteen patients (87.5%) experienced significant pain relief