Front Endocrinol 14:1240263 Vora LK, Gholap AD, Jetha K, Thakur RRS, Solanki HK, Chavda VP (2023) Artificial intelligence in pharmaceutical technology and drug delivery design
The isoelectric point of semaglutide sits around pH 5.4, and degradation accelerates significantly between pH 4.5 and 5.5, which means that any formulation changes caused by temperature exposure can compound the problem by shifting the solution toward less stable conditions
Back Rehfeld, JF (2012) 'Beginnings: A reflection on the history of gastrointestinal endocrinology', Regulatory Peptides , 177, S1-S5
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Patients considering taking it should undergo a physical exam to determine suitability for tirzepatide injections