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These are pathway-level: they describe the metabolic terrain a clinician is prescribing into rather than predicting a specific response

Similarly, TFEB-mediated autophagy played a crucial role in the protective effects of UA in BV2 cells by upregulating the expressions of Beclin-1, LAMP1, and the LC3II/I ratio, while the knockdown of TFEB by siRNA markedly decreased autophagy activity in A + UA-treated BV2 cells

In aged rats with induced cognitive deficits, Dihexa restored memory performance to levels comparable to healthy young animals through structural increases in dendritic spine density

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Some researchers have speculated that patients in certain clinical trials, particularly the CASTA stroke trial, may have received inadequate doses, potentially explaining the mixed results in the overall population analysis