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Lilly's dual GLP-1/GIP agonist reached Phase 3 in 2019 and read out body-weight reductions of roughly 22% at the 15 mg dose in SURMOUNT-1, meaningfully above semaglutide's ~15%
When GLP-1 medications enter the body, they bind to the receptors in the brain and work in several ways to support metabolic health
50 Contrary to preclinical literature about the positive role of GLP-1 RAs on the rewarding and reinforcing behavior of drug abuse, the study in our review proposed that exenatide treatment did not help with euphoria and cocaine craving in the subjects
Figure 5e and f depict volcano plots highlighting the variations in tirzepatide-related signals across outcome subgroups
Future research should examine the potential role of GLP-1RAs in the treatment and prognosis of psychiatric and neurodevelopmental conditions
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