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Summary Semaglutide is a synthetic analogue of the naturally occurring glucagon-like peptide-1 (GLP-1), which plays a critical role in regulating glucose metabolism, appetite, and energy balance1,2
Comparison of the exendin-4 and exendin-P5 bound (PDB 6B3J) structures revealed similarities in their ECD location and greater similarities of the backbone orientations for TMs 15, relative to the GLP-1-bound and oxyntomodulin-bound complexes (Fig
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