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Gradual dose titration the standard clinical approach significantly reduces the severity and frequency of adverse effects

Radical resection of the pyloric antrum and its effect on gastric emptying after sleeve gastrectomy

After 40 weeks of treatment, tirzepatide demonstrated significant reductions in HbA1c: -2.01% at 5 mg, -2.24% at 10 mg, and -2.30% at 15 mg

This side effect is often most noticeable when first starting treatment or after a dose increase, which is why most protocols begin at a lower dose and increase gradually over time

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes