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doi:10.1016/j.bone.2005.04.017

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P., Dong, F

46 Our observation of inconsistent autophagy dependency in patient-derived organoids (PDOs) under vertical RAS pathway inhibition may be due to the shorter time spans of 3D culture conditions (only 72 h compared with 2D assays with 714 days, allowing compensatory mechanisms to become more relevant) and/or the lower proliferative activity and more complex architecture of PDOs, including 3D cellcell interactions and oxygen/nutrient gradients, which may affect the regulation and necessity of autophagy differently than 2D cultures do