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Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)

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192,193 In a metabolomics study, the levels of cysteine were inversely related to overall glioma risk, being lower in the circulation of glioma patients compared with controls years in advance of diagnosis

Cheng J, Mi P, Li Y, Lu Y, Sun F