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10.1002/14651858.CD005195.pub4 195 WaldE

The reasons are multifaceted: rodent models of neurodegeneration imperfectly recapitulate human disease

Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)

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DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations