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Expressing a thiol-containing sensor such as roGFP2-Orp1 under a high-level constitutive promoter might disturb ER redox homeostasis, causing reductive stress (Ugalde et al ., 2022 a ), resulting in secretion of proteins with reduced thiols

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TB-500 is a synthetic analog of the Thymosin Beta-4 protein fragment (CAS 77591-33-4), a 43-amino acid peptide found at high concentrations in platelets, wound fluid, and virtually all human and animal cells