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& Cooper, A
Patients should stop the medication and contact their healthcare provider immediately if they experience: Severe or persistent abdominal pain (especially if radiating to the back), which could indicate pancreatitis Persistent vomiting preventing adequate fluid intake Signs of dehydration (dark urine, dizziness, reduced urination) Yellowing of skin or eyes (jaundice) or pale stools Unexplained fever Severe diarrhoea lasting more than 48 hours Treatment continuation is reviewed regularly, with decisions based on efficacy, tolerability, and ongoing clinical need
Both liraglutide and semaglutide have been shown to reduce obesity-induced muscle atrophy via a GLP-1/Sirtuin (SIRT1) pathway in rodents ( in vitro models
In line with our data showing that GLP-1RA/tesaglitazar only induces PPAR/RXR heterodimerization in the presence of GLP-1R (Fig
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