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Unlike lyophilised powderwhich tolerates freezing because water content is below 3%reconstituted solutions contain 9799% water, and the expansion during freezing is mechanically destructive

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4) Imbruvica (ibrutinib) Imbruvica is approved for the following indications: Adults with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)

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Administration caution : Use appropriate formulation and route (e.g., injection, transdermal, buccal, etc.)

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