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PMCID: PMC5338159

As discussed in the section on inducers of eryptosis, numerous antitumor agents have demonstrated proeryptotic activity in vitro

Large cardiovascular trials and pooled analyses have not shown a statistically higher pancreatitis incidence than placebo beyond what is expected in diabetics (who inherently have some risk)

In addition to the physiological functions of protein-bound lipoic acid, there is increasing scientific and medical interest in potential therapeutic uses of pharmacological doses of free (unbound) lipoic acid (3)