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A summary of the risk of bias assessment is shown in Fig
This persistent lack of oxygen and blood flow prevent the tenocytes from repairing the matrix
These ROS can damage DNA, proteins and cell lipids and cause inflammation and cellular damage
They share the identical 43-amino acid sequence
However, further investigations are needed to place Gremlin1 into the gene regulatory network that establishes the fibrotic response of LECs PLI and answer whether Gremlin1 is directly involved in myofibroblast production PLI
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