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10.1007/978-3-319-66682-2_10 Glutathione in Plant Growth, Development, and Stress Tolerance 7 ChronopoulouE

However, one study on the treatment of children with methylmalonic acidemia and homocystinuria found oral hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine

in contrast, GSS knockout depletes GSH but still permits glutamate consumption for -glutamyl-peptide synthesis, and does not alter ferroptosis sensitivity under cystine starvation

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Endogenous creatine synthesis also consumes methyl groups, so high creatine demand may place additional pressure on SAM-dependent methylation