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The gastric balloon could be an option for patients who are not good candidates for surgery or dont respond well to weight-loss drugs, Traverso says

Patients should contact their GP or prescribing clinician if they experience: Severe or persistent cramps that do not respond to simple measures or significantly impact daily activities and sleep quality Frequent cramping occurring multiple times daily or nightly Associated symptoms such as muscle weakness, numbness, tingling, or changes in sensation, which may indicate neurological involvement Visible muscle changes including swelling, redness, tenderness, or asymmetry between legs Signs of dehydration such as dizziness, reduced urine output, dark urine, or confusion These features may indicate underlying conditions requiring investigation, such as significant electrolyte disturbances, peripheral neuropathy (particularly relevant in diabetes), peripheral arterial disease, or, rarely, more serious muscle disorders

This makes Tirzepatide useful for studying receptor signaling, cell communication, and differences between laboratory models

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Front Mol Neurosci 13:84 Elibol B, Beker M, Sahbaz CD, Kilic U, Jakubowska-Doru E (2019) Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus