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Compared with the initiation of sulfonylurea, the addition of SGLT2is to GLP-1RA therapy was associated with a significantly lower incidence rate of the composite cardiovascular endpoint (9.9 versus 13.0 per 1,000 person-years

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This has led to its voluntary phase-out from vaccines in a number of countries such as Japan

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The total global revenue from Darzalex was $7.98 billion in 2022, a 32.44 percent increase from $6.02 billion in 2021