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doses were escalated after 5 days from 5 to 10 mg in all multiple-dose trials except in the dosing conditions trial (NCT01572753) [15], in which 10 mg was dosed for 10 days
We now know that this older vascular theory of migraine is defunct and disproven, and that migraine aura symptoms are of an electrical neurological cause ( cortical spreading depression ), and not a vascular cause
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