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This extended half-life is achieved through structural modifications that reduce renal clearance and proteolytic degradation, including a C20 fatty diacid moiety that promotes albumin binding and protects the molecule from enzymatic breakdown
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PET-NP exposure resulted in a higher mortality incidence in both MI + NP-exposed mice, who received 50 g/ml oral PET-NPs, and in mice exposed to PET-NPs by aerosol inhalation (12-h continuous exposure to PET-NPs at 1 mg/m3 by aerosol inhalation every day for 3 months)
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