semaglutide o tirzepatide vs. for Weight Loss A new study suggests GLP-1s

Fat cell enlargement is an independent marker of insulin resistance and 'Hyperleptinaemia'

67 However, our results did not show changes in lactate production, which suggests a higher association with adipocytes genesis

Include weekly weights, monthly measurements, any side effects and their severity, and notes on eating habits and activity levels

Trials with older GLP-1 drugs (liraglutide, exenatide) including the large ADJUNCT ONE and ADJUNCT TWO studies showed modest HbA1c improvements of 0.10.7%, meaningful weight loss, and lower insulin requirements, but also raised early concerns about hypoglycemia and ketosis that kept enthusiasm in check for years

Small animal rat model Six-week-old male Sprague-Dawley rats were obtained from Shanghai Lab, Animal Research Center Co