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A study found, Parenteral vitamin B12 is more effective than oral supplementation in patients with severe deficiency or malabsorption. In summary, B12 injections are essential for treating many health conditions and absorption problems

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11 Its also important to note that taking B12 in combination with vitamin B6 and folate (rather than alone) is shown to be most effective for regulating homocysteine levels for some patients and preventing the combined risk of stroke, myocardial infarction (heart attack), and damage to heart cells