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Sulforaphane supplementation has been shown to increase hepatic and blood glutathione levels in human studies (Fahey et al., Proc Natl Acad Sci, 1997
Consequently, mitochondria are of great importance for connecting oxidative stress and aging, making them a key target for therapeutic interventions aimed at mitigating age-related diseases
These substances are often considered as risk factors for the development of cancer and thus act as indicators of endogenous oxidative DNA damage [46]
Semin Neurol 35:83100 Acknowledgements The authors would like to gratefully acknowledge and thank Bruna Klippel Ferreira for her excellent effort in preparing Figs
OS has also been implicated in the process of ovarian ageing and an increased incidence of aneuploidy in ageing oocytes
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