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The FDA does not pre-approve compounded medications, but 503A pharmacies operate under strict USP standards and state pharmacy board oversight that ensure consistent quality and sterility

For many others, digestive symptoms improve as the body adjusts to the medication

That branded compounding market, however, is both clogged with companies looking to cash in on the GLP-1 craze and, more importantly, rife with safety and quality control concerns

Here a double-blinded, randomized (1:1), placebo-controlled trial using semaglutide 2.4 mg weekly (BARI-STEP) recruited adult participants at least 1 year after gastric bypass or sleeve gastrectomy with a suboptimal clinical response, defined as less than 20% weight loss from surgery

It is FDA-approved only for people with type 2 diabetes